Serosurvey in SARS-CoV-2 inactivated vaccine-elicited neutralizing antibodies against authentic SARS-CoV-2 and its viral variantsArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome Administered Antibody neutralization BBIBP-CorV Beta booster vaccination circulating CoronaVac coronavirus Delta Eta Gamma humoral immune response immune immune response inactivated Inactivated vaccine individual Lineage lineages morbidity and mortality Mutation neutralization neutralization titer neutralize neutralized Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody response omicron reduce SARS-CoV-2 SARS-CoV-2 variant second vaccination serum sample significantly lower the SARS-CoV-2 vaccine dose variant viral variant Viral variants Viral variants. virus virus strain viruses wild-type [DOI] 10.1002/jmv.28049 PMC 바로가기
Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds양이온성 양친매성 스테로이드 화합물의 항 SARS-CoV-2 활성의 확인 및 특성화Article Published on 2022-12-012022-09-11 Journal: Virulence [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] aggravation ameliorated anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity Antiviral antiviral activity cationic caused cell lines characterization cholesterol complex Compound compounds COVID-19 pandemic COVID-19 patient cytopathic Cytopathic effect Drug discovery effective envelope envelope proteins epiandrosterone followed by hACE2 HEK293 host cell host cells identification in vitro in vivo indicated inhibited initial involved life Lipid mechanism membrane modulate modulation Mortality Pathogenesis progeny protective effect Protective effects Proteins Quality of life reduce reduce COVID-19 aggravation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selected Selection single mutation single mutations specific treatment spike steroidal compounds. subversion Transgenic mouse translate transmembrane Treatment treatment of COVID-19 patients Vero Vero CCL81 cell Vero CCL81 cells viral replication Viral RNA viral variant Viral variants [DOI] 10.1080/21505594.2022.2085793 PMC 바로가기 [Article Type] Article
The immune response as a double-edged sword: The lesson learnt during the COVID-19 pandemicArticle Published on 2022-11-012022-11-16 Journal: Immunology [Category] SARS, 변종, [키워드] Asymptomatic breadth cellular Clinical severity COVID-19 COVID-19 pandemic Critical Cross-immunity cytokine Cytokine storm detrimental disease disease severity effort events Evidence feature highlighting immune response Immunopathogenesis Infection Innate immunity pathogen pathogenic processes Protective protective immunity protective immunity. protective role provided public health reducing resulting T-cell immunity the SARS-CoV-2 therapeutic approaches tissue injury Vaccine Viral variants [DOI] 10.1111/imm.13564 PMC 바로가기
Immunoassay and mass cytometry revealed immunological profiles induced by inactivated BBIBP COVID-19 vaccineArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] analyzed antibody Antibody titer B cell booster booster dose caused Cell Cluster Concentration conducted COVID-19 COVID-19 vaccine CyTOF Cytometry declined decrease distribution Efficacy ENhance healthy highlight humoral Immune cell immune response Immunity immunization immunoassay immunoassay. immunological profile inactivated individual injection Injections lack maintain marker multicenter neutralizing antibody not significantly different participant prevalence of COVID-19 proportion protective effect recall receiving recruited reduced SARS-CoV-2 second dose serum antibody shown significantly significantly increased Still subject surface marker sVNT the antibody response the vaccine vaccination Vaccine vaccine doses vaccine injection Viral variants virus neutralization test [DOI] 10.1002/jmv.27983 PMC 바로가기
Boosting with Multiple Doses of mRNA Vaccine after Priming with Two Doses of Protein Subunit Vaccine MVC-COV1901 Elicited Robust Humoral and Cellular Immune Responses against Emerging SARS-CoV-2 VariantsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome antibody AZD1222 booster vaccination cellular Cellular immune response cellular immune responses cellular immunity coronavirus COVID-19 Delta delta variant dose effective elevated elicit Emergency use authorization emerging variants evaluated Evidence Heterologous heterologous prime-boost heterologous vaccination humoral immune immune evasion immune response immune responses IMPROVE increase in induce Infection interferon mRNA mRNA vaccine mRNA-1273 Multiple Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody omicron Prevent priming promote Protein subunit protein subunit vaccine provided RBD Receptor binding domain reduced regimen response SARS-CoV-2 SARS-CoV-2 variants significantly subunit suggested T cell Taiwan vaccination vaccination schedule Vaccine variant variants Viral variants Viral variants. wild type [DOI] 10.1128/spectrum.00609-22 PMC 바로가기
Sensitivity analysis of rapid antigen tests for the Omicron SARS-CoV-2 variant detection from nasopharyngeal swab samples collected in Santiago of ChileArticle Published on 2022-10-202022-11-15 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis Antigen circulation collected Contagion contagiousness COVID-19 COVID-19 pandemic decrease Detection sensitivity evaluate faster genomic greater Health authority highlight immune evasion increasingly indicate Infection limit Local Mutation nasopharyngeal swab sample NPSs omicron Omicron detection outbreak pandemic pandemic in Chile Patient predominant Prevent rapid antigen test rapid antigen test. RAT RATs reduce RT-PCR RT-qPCR SARS-CoV-2 SARS-CoV-2 variant sensitivity suggested tested the SARS-CoV-2 virus variant viral amplification Viral load viral loads Viral variants VoC [DOI] 10.3389/fpubh.2022.976875 PMC 바로가기
SARS-CoV-2 Variant-Specific Infectivity and Immune Profiles Are Detectable in a Humanized Lung Mouse ModelArticle Published on 2022-10-162022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] animal model B.1.1.7 B.1.1.7 variant expected greater higher infectivity Human immune system human lung tissue humanized humanized mice immune cells Immune profile immune response Immunity Infection Infectivity lesion Lineage lung lung organoid mice Model mouse no difference overlapping Pathogenesis pathogenesis of SARS-CoV-2 profile replication of SARS-CoV-2 required Research SARS-CoV-2 SARS-COV-2 infection similarity Support supported sustained Th1 Th2 variant variants of concern variants of concern. Viral load viral variant Viral variants virus [DOI] 10.3390/v14102272 PMC 바로가기
Estimating SARS-CoV-2 variant fitness and the impact of interventions in England using statistical and geo-spatial agent-based models통계 및 지리 공간 에이전트 기반 모델을 사용하여 SARS-CoV-2 변종 적합도 및 영국에서의 개입 영향 추정Article Published on 2022-10-032022-09-11 Journal: Philosophical transactions. Series A, Mathematical [Category] COVID19(2023년), SARS, 변종, [키워드] agent agent-based model Alpha B.1.1.7 B.1.177 death distribution dominant variant effective England Epidemics estimate Evolution example geo-spatial model Intervention Lineage lockdown lockdowns prevented relative reopening replaced REPLACED BY Reproduction number robustness SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 variant Spread statistical statistical model the epidemic Transmissibility vaccination Vaccinations variant variants Variation Viral variants virus variants virus variants. [DOI] 10.1098/rsta.2021.0304 PMC 바로가기 [Article Type] Article
COVID-19 Symptoms and Duration of Rapid Antigen Test Positivity at a Community Testing and Surveillance Site During Pre-Delta, Delta, and Omicron BA.1 PeriodsArticle Published on 2022-10-032022-11-16 Journal: JAMA Network Open [Category] COVID19(2023년), SARS, 변종, [키워드] addition age Antigen Asymptomatic booster children clinical symptom Community conducted cough COVID-19 COVID-19 symptom COVID-19 testing cross-sectional Delta Duration Evolution Fever first positive Fisher Health Isolation Latinx less loss of taste median myalgia negative test omicron outcome participant Participants Patient Period population immunity positive positive result positive test result Practitioner proportion public health Rapid remained repeated reported reported symptoms San Francisco SARS-COV-2 infection seeking Site sore throat Symptom symptom onset symptomatic symptomatic participant Symptoms Test tested Testing upper respiratory tract vaccination Vaccine variant Viral variants were used with COVID-19 worsening χ2 test [DOI] 10.1001/jamanetworkopen.2022.35844 PMC 바로가기
The next frontier in vaccine design: blending immune correlates of protection into rational vaccine designReview Published on 2022-10-012022-10-05 Journal: Current opinion in immunology [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, [키워드] accelerate accelerated antibody Antibody binding canonical Community Complete death embedding immune correlate Immune profile Immunity immunological lack neutralization pathogen populations protective vaccines question raised severe disease the vaccine to define Vaccine Vaccine design Vaccine development Vaccines variants of concern Viral variants waned [DOI] 10.1016/j.coi.2022.102234 [Article Type] Review